Along the Meguro River, there are small, individually owned restaurants and shops in the town of Nakameguro, near Ebisu. You can get there on the Hibiya subway line or Tokyu Toyoko Line.
During the daytime, it is a nice walking trail. There are cozy cafes, shops, beauty salons and a park along the river to look around.
In the evening, you can enjoy a variety of good food at these trendy restaurants. You will need to make your reservation in advance because a lot of them book up very quickly. My favorite restaurant here is a Hawaiian one but it is always booked when I call them. Their fried shrimp is so delicious and addictive.